Pep Guardiola will be without star striker Gabriel Jesus after he limped out of City’s 0-0 draw against Crystal Palace with a medial collateral ligament injury.
The game also saw Kevin De Bruyne limp off after a hefty challenge as Manchester City’s 18-game winning streak came to end at Selhurst Park.
Watford are on a dismal run of form, with Marco Silva’s side having lost five out of their last six games in the Premier League.
So how will Guardiola alter his side for this Premier League clash? Scroll through the gallery above to see talkSPORT’s predicted Manchester City line-up in squad number order…