Liverpool are scheduled to face Everton at 2:15pm but poor weather has led to fears the game may be called off.
The Met Office has issued amber warnings for snow in the UK and Liverpool have made a short statement calling on supporters of both clubs to get to Anfield well ahead of kick off.
Liverpool tweeted: “Due to the inclement weather forecast and snowfall across the country, #LFC would like to remind supporters to take extra care when travelling to Anfield.
“Supporters are encouraged to arrive early where possible and check the Merseytravel and Merseyrail websites for any updates.”
Bookmaker Paddy Power have slashed the odds on the Merseyside and Manchester derbies being called off.
They’ve offered odds of 10/1 that the Merseyside derby is called off and 12/1 that the top-of-the-table clash between Manchester United and City is also postponed.
And it is 66/1 that all three of today’s Premier League matches have to be re-scheduled, including Southampton vs Arsenal.
Spokesman Paddy Power said: “Apparently (White) Christmas has come early to the UK, and it could put today’s big fixtures on ice.
“Knowing Jose Mourinho, he’s probably confiscated all salt from the Old Trafford area, so to delay his side having to face runaway leaders Man City – who we’ve already paid out on winning the title.”
The Met Office released a statement earlier today which read: “Road, rail and air travel delays are likely, as well as stranding of vehicles and public transport cancellations.
“There is a good chance that some rural communities could become cut off.”