The north Londoners are struggling for form in the Premier League, and Pochettino wants to keep his key players fresh for Saturday’s visit of Stoke to give them the best chance of victory.
With such a weakened squad named, Apoel will sense the possibility of finishing third in Group H and qualifying for the Europa League ahead of Borussia Dortmund.
BVB currently sit third, but if Apoel better Dortmund’s result against Real Madrid in Group H’s other match, they will move ahead of the Germans.
So, who has been selected for the clash at Wembley? The confirmed teams can be seen, in full, below…
Tottenham Hotspur XI: Vorm, Rose, Sanchez, Foyth, Aurier, Winks, Sissoko, N’Koudou, Alli, Son, Llorente
Substitutes: Gazzaniga, Davies, Vertonghen, Walker-Peters, Amos, Dembele, Sterling
Apoel Nicosia XI: Perez, Lago, Rueda, Ebecilo, Pote, Vinicius, Zahid, Morais, Vouros, Aloneftis, Carlao
Substitutes: Gudino, De Camargo, Alexandrou, Sallai, Antoniou, Farias, Merkis