Oxlade-Chamberlain is one of five changes made by Klopp with Mane forced to settle for a place on the bench alongside Roberto Firmino.
And in his pre-match interview, Klopp suggested there was not much difference between Oxlade-Chamberlain and Mane.
Klopp said: “I would say Ox would play similar to how Sadio plays with his own specific skills of course involved.
Dejan Lovren was left out of the squad due to injury and replaced by Joel Matip.
But Klopp insisted he has confidence in his squad.
He added: “Dejan Lovren is not able to play, he’s a little bit injured, like Emre, so that’s the reason for that change.
“We need to use the quality of the squad. I have absolute trust in the squad but then I have to show it. We cannot let the other boys play until they can’t play anymore, I said it before, so that’s why we change.
“We have fresh legs in, still quality with fantastic options to change in the game – so, good.”
Liverpool: Mignolet, Gomez, Klavan, Matip, Moreno, Henderson, Milner, Coutinho, Salah, Sturridge, Oxlade-Chamberlain